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Sometimes during surgery to remove a tumor, cells become detached from the bulk of the neoplasm. In a small identification number of cases, these neoplasm cells stick to cells at the site of the surgical wound and go on to form a secondary tumor, having an enormous negative impact on the survival and quality of life of the affected role. New information, generated by Marc Basson and colleagues, at the John D. Dingell VA Medical Center and Wayne State University, Detroit, exploitation a mouse model of surgery to remove a colon cancer tumor, indicate that perioperative treatment with a dose known as colchicine power decrease the incidence of tumor formation at the site of the surgical wound.
When colon cancer tumour cells are exposed to high atmospheric pressure they march an increased ability to stick to other cells. In the study, to mimic the conditions of surgery, the authors remote colon cancer cells from one black eye, exposed them to high pressure in vitro, and then transplanted them into a second mouse that they monitored for the development of tumors at the site of the surgical lesion. The to the highest degree important observation made was that if the mice from which the el Salvadoran colon cancer cells came from were treated perioperatively with colchicine in that location was a dramatic decrease in the number of tumors that formed at the web site of the surgical injury in the second mouse. As in vitro exposure of neoplasm cells from breast and head and neck cancers to high pressure also increases their ability to stick to other cells it is possible that these information might receive implications in several clinical settings.
TITLE: Colchicine inhibits press-induced tumor cellular telephone implantation within surgical wounds and enhances tumor-free survival in mice
AUTHOR:
Marc D. Basson
John D. Dingell VA Medical Center and Wayne State University, Detroit, Michigan, USA.
http://www.va.gov
View the PDF of this article here
Source:
Karen Honey
Journal of Clinical Investigation
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